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Page 1
Glial cell line-derived neurotrophic factor/neurturin-induced differentiation and its enhancement by retinoic acid in primary human neuroblastomas expressing c-Ret, GFR alpha-1, and GFR alpha-2.
Hishiki T, Nimura Y, Isogai E, Kondo K, Ichimiya S, Nakamura Y, Ozaki T, Sakiyama S, Hirose M, Seki N, Takahashi H, Ohnuma N, Tanabe M, Nakagawara A. Hishiki T, et al. Cancer Res. 1998 May 15;58(10):2158-65. Cancer Res. 1998. PMID: 9605760
Here, we studied the effect of GDNF and NTN on human neuroblastomas in the short-term primary culture system, as well as the expression of c-Ret, GFR alpha-1, GFR alpha-2, GDNF, and NTN. ...Many primary neuroblastomas expressed c-Ret, GFR …
Here, we studied the effect of GDNF and NTN on human neuroblastomas in the short-term primary culture system, as well as the expressi …
Glial cell line-derived neurotrophic factor and neurturin inhibit neurite outgrowth and activate RhoA through GFR alpha 2b, an alternatively spliced isoform of GFR alpha 2.
Yoong LF, Too HP. Yoong LF, et al. J Neurosci. 2007 May 23;27(21):5603-14. doi: 10.1523/JNEUROSCI.4552-06.2007. J Neurosci. 2007. PMID: 17522305 Free PMC article.
Using highly specific and sensitive quantitative real-time PCR, these isoforms were found to be expressed at comparable levels in various regions of the human brain. When stimulated with GDNF and NTN, both GFR alpha2a and GFR alpha2c, but not GFR alpha …
Using highly specific and sensitive quantitative real-time PCR, these isoforms were found to be expressed at comparable levels in various re …
GFR alpha-4 and the tyrosine kinase Ret form a functional receptor complex for persephin.
Enokido Y, de Sauvage F, Hongo JA, Ninkina N, Rosenthal A, Buchman VL, Davies AM. Enokido Y, et al. Curr Biol. 1998 Sep 10;8(18):1019-22. doi: 10.1016/s0960-9822(07)00422-8. Curr Biol. 1998. PMID: 9740802 Free article.
GDNF and neurturin signal through multicomponent receptors that consist of the Ret receptor tyrosine kinase and one of two structurally related glycosyl-phosphatidylinositol (GPI)-linked ligand-binding subunits: GFR alpha-1 is the preferred ligand-binding subunit for GDNF, …
GDNF and neurturin signal through multicomponent receptors that consist of the Ret receptor tyrosine kinase and one of two structurally rela …
Plasma leucine-rich alpha-2-glycoprotein 1 - a novel marker of diabetic kidney disease in children and adolescents with type 1 diabetes mellitus?
Altıncık SA, Yıldırımçakar D, Avcı E, Özhan B, Girişgen İ, Yüksel S. Altıncık SA, et al. Pediatr Nephrol. 2023 Dec;38(12):4043-4049. doi: 10.1007/s00467-023-06019-4. Epub 2023 Jul 4. Pediatr Nephrol. 2023. PMID: 37401956
BACKGROUND: Glomerular endothelial dysfunction and neoangiogenesis play a significant role in the pathogenesis of diabetic kidney disease (DKD). Leucine-rich alpha-2 glycoprotein 1 (LRG1) is a recently discovered protein that participates in the molecular pathway of …
BACKGROUND: Glomerular endothelial dysfunction and neoangiogenesis play a significant role in the pathogenesis of diabetic kidney disease (D …
Effects of alpha 2-adrenergic blockade on renal hemodynamics in patients with insulin dependent diabetes mellitus.
Jacobson SH, Ostenson CG. Jacobson SH, et al. Diabetes Res Clin Pract. 1991 Dec;14(3):197-203. doi: 10.1016/0168-8227(91)90021-5. Diabetes Res Clin Pract. 1991. PMID: 1685705
The role of renal alpha 2-adrenoceptors in the regulation of glomerular filtration and renal perfusion is unknown. ...Volume expansion, achieved by infusion of isotonic sodium chloride solution, during placebo infusion induced a significant drop in GFR in hea …
The role of renal alpha 2-adrenoceptors in the regulation of glomerular filtration and renal perfusion is unknown. ...Volume e …
Identification of a surface for binding to the GDNF-GFR alpha 1 complex in the first cadherin-like domain of RET.
Kjaer S, Ibáñez CF. Kjaer S, et al. J Biol Chem. 2003 Nov 28;278(48):47898-904. doi: 10.1074/jbc.M309772200. Epub 2003 Sep 26. J Biol Chem. 2003. PMID: 14514671 Free article.
We found that Xenopus RETECD was unable to bind to GDNF-GFR alpha-1 or neurturin (NTN)-GFR alpha-2 complexes of mammalian origin. ...Subsequent loss-of-function experiments at higher resolution identified three small subsets of residues, mapping on the …
We found that Xenopus RETECD was unable to bind to GDNF-GFR alpha-1 or neurturin (NTN)-GFR alpha-2 complexes of …
Quantification of mouse glial cell-line derived neurotrophic factor family receptor alpha 2 alternatively spliced isoforms by real time detection PCR using SYBR Green I.
Wong YW, Sia GM, Too HP. Wong YW, et al. Neurosci Lett. 2002 Mar 8;320(3):141-5. doi: 10.1016/s0304-3940(01)02282-0. Neurosci Lett. 2002. PMID: 11852182
Both NTN and GDNF have been shown to potently prevent the degeneration of dopaminergic neuron in vitro and in vivo. The GDNF family receptor alpha 2 (GFR alpha-2) is the preferred receptor for NTN. In addition to the known full-length isoform ( …
Both NTN and GDNF have been shown to potently prevent the degeneration of dopaminergic neuron in vitro and in vivo. The GDNF family receptor …
Multiple GPI-anchored receptors control GDNF-dependent and independent activation of the c-Ret receptor tyrosine kinase.
Trupp M, Raynoschek C, Belluardo N, Ibáñez CF. Trupp M, et al. Mol Cell Neurosci. 1998 May;11(1-2):47-63. doi: 10.1006/mcne.1998.0667. Mol Cell Neurosci. 1998. PMID: 9608533
GFR alpha-2, but not GFR alpha-3 mRNA expression was highly induced in several nuclei after stimulation with kainic acid. In contrast to GFR alpha-1 and GFR alpha-2, GFR alpha-3 expression in postnatal and adult brain …
GFR alpha-2, but not GFR alpha-3 mRNA expression was highly induced in several nuclei after stimulation with kai …
GDNF and NGF family members and receptors in human fetal and adult spinal cord and dorsal root ganglia.
Josephson A, Widenfalk J, Trifunovski A, Widmer HR, Olson L, Spenger C. Josephson A, et al. J Comp Neurol. 2001 Nov 12;440(2):204-17. doi: 10.1002/cne.1380. J Comp Neurol. 2001. PMID: 11745618
The percentage of adult human DRG cells expressing p75, trkA, trkB, or trkC was 57, 46, 29, and 24%, respectively, and that of DRG cells expressing RET, GFR alpha-1, GFR alpha-2, or GFR alpha-3 was 79, 20, 51, and 32%, respectively. ...Me …
The percentage of adult human DRG cells expressing p75, trkA, trkB, or trkC was 57, 46, 29, and 24%, respectively, and that of DRG ce …
Adrenergic blocking agents and the kidney.
Bauer JH. Bauer JH. J Clin Hypertens. 1985 Sep;1(3):199-221. J Clin Hypertens. 1985. PMID: 2872278 Review.
The acute and chronic renal effects of the beta-adrenergic antagonists, alpha 1-adrenergic antagonists, central alpha 2-adrenergic agonists, and central and/or peripheral adrenergic-neuronal blocking agents are reviewed. ...The central alpha 2-adrenerg …
The acute and chronic renal effects of the beta-adrenergic antagonists, alpha 1-adrenergic antagonists, central alpha 2-adrene …
35 results